Structured Evidence Base
Curated, classified, and continuously updated.
The literature operating beneath the BAM framework. Tier-classified by methodology. System-mapped against the system architecture. Reviewed on a defined cadence.
Library Composition
Strong Evidence
292
Moderate Evidence
60
Emerging Evidence
425
Contextual Foundations
0
Total References
777
Four Tiers · Methodology-graded
Every reference enters the library at one of four tiers, classified by study methodology rather than topic appeal. Tier discipline is what separates a structured evidence base from a citation list.
292
T-01
Strong Evidence
Meta-analyses · Large RCTs · Cochrane
60
T-02
Moderate Evidence
Cohort · Prospective · Longitudinal
425
T-03
Emerging Evidence
Reviews · Mechanistic · Pilot · Case
0
T-04
Contextual Foundations
Textbooks · Narrative · Historical
Nine Systems · One Taxonomy
Every reference mapped against the same architecture operated by the Index.
D-01
Structural
777 refs
D-02
Oral-Systemic
0 refs
D-03
Metabolic
0 refs
D-04
Neurological
0 refs
D-05
Autonomic
0 refs
D-06
Recovery
0 refs
D-07
Toxic
0 refs
D-08
Regenerative
0 refs
D-09
Hormonal &
Endocrine
0 refs
Evidence Integration Model
How the Library Feeds the System
Evidence is not displayed. It is operated. Each reference flows into one of three integration points — none of them ornamental.
I-01
System Scoring
Tier 1–2 evidence calibrates the threshold curves used to score each system. The framework refuses to assign a system weight that lacks a strong-or-moderate evidence anchor.
F-02
Cross-System Relationships
Tier 1–3 evidence supports the cross-system correlation map — the interaction profile that distinguishes BAM from single-biomarker models.
F-03
System Output
Evidence governs how composite ALRI is constructed, classified, and translated into governance-grade output. Every banding decision traces back to a documented source.
Literature → Tier Classification → System Mapping → Integration → ALRI
Search by System, Tier, or Relevance
The library is exposed in full under structured query — never as a flat catalogue. Filter by tier, by system, or by keyword to inspect the references underneath any framework decision.
TIER 3
D-01 · Structural
On the Concept of Health Capital and the Demand for Health
Grossman M. · 1972 · J Political Economy, 1972
TIER 3
D-01 · Structural
The economic value of targeting aging
Scott AJ, Ellison M, Sinclair DA. · 2021 · Nature Aging, 2021
TIER 3
D-01 · Structural
Does Preventive Care Save Money?
Cohen JT, Neumann PJ, Weinstein MC. · 2008 · NEJM, 2008
TIER 3
D-01 · Structural
Systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized, participatory
Hood L, Flores M. · 2012 · New Biotechnology, 2012
TIER 1
D-01 · Structural
General health checks in adults for reducing morbidity and mortality
Krogsboll LT et al. · 2012 · BMJ (Cochrane), 2012
TIER 3
D-01 · Structural
DNA methylation age of human tissues and cell types
Horvath S. · 2013 · Genome Biology, 2013
TIER 2
D-01 · Structural
DunedinPACE, a DNA methylation biomarker of the pace of aging
Belsky DW, Caspi A et al. · 2022 · eLife, 2022
TIER 3
D-01 · Structural
Epigenetic-based age acceleration: associations with aging-related morbidity and mortality
Faul JD et al. · 2023 · PNAS, 2023
TIER 3
D-01 · Structural
Heavy Metal Exposure and Cardiovascular Disease
Pan Z et al. · 2024 · Circulation Research, 2024
TIER 2
D-01 · Structural
Toxic metals and chronic kidney disease
Moody EC et al. · 2018 · Curr Environ Health Reports, 2018
TIER 3
D-01 · Structural
35 meta-analyses, 29M+ participants
Heavy metal umbrella review · 2024 · J Hazardous Materials, 2024
TIER 3
D-01 · Structural
Long-term PM2.5 exposure and mortality (WHO-commissioned)
Orellano P et al. · 2024 · Int J Public Health, 2024
TIER 3
D-01 · Structural
TIER 3
D-01 · Structural
Persistent organic pollutants and metabolic disease risk
Ruzzin J et al. · 2012 · BMC Public Health, 2012
TIER 3
D-01 · Structural
Modulation of Metabolic Detoxification Pathways Using Foods
Hodges RE et al. · 2015 · J Nutr Metab, 2015
TIER 3
D-01 · Structural
Genetic Biomarkers of Metabolic Detoxification for Personalized Lifestyle Medicine
Aronica L et al. · 2022 · Nutrients, 2022
TIER 3
D-01 · Structural
Diversity, stability and resilience of the human gut microbiota
Lozupone CA et al. · 2012 · Nature, 2012
TIER 3
D-01 · Structural
The Microbiota-Gut-Brain Axis
Cryan JF et al. · 2019 · Physiological Reviews, 2019
TIER 3
D-01 · Structural
Interaction between microbiota and immunity
Zheng D, Liwinski T, Elinav E. · 2020 · Cell Research, 2020
TIER 3
D-01 · Structural
Gut microbiota associated with immune cell dynamics in humans
Schluter J, Peled JU et al. · 2020 · Nature, 2020
TIER 3
D-01 · Structural
Natural cytotoxic activity and cancer incidence: 11-year follow-up
Imai K et al. · 2000 · The Lancet, 2000
TIER 3
D-01 · Structural
NK cell-mediated immunosurveillance of human cancer
Malmberg KJ et al. · 2017 · Semin Immunol, 2017
TIER 1
D-01 · Structural
Leukocyte count and all-cause/cardiovascular mortality: meta-analysis
Park C et al. · 2023 · Am J Cardiol, 2023
TIER 3
D-01 · Structural
CRP and risk of CHD, stroke, and mortality
Kaptoge S et al. · 2010 · The Lancet, 2010
TIER 2
D-01 · Structural
hs-CRP and all-cause, cardiovascular, and cancer mortality
Li Y et al. · 2017 · Atherosclerosis, 2017
TIER 3
D-01 · Structural
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci L et al. · 2018 · Nature Reviews Cardiology, 2018
TIER 3
D-01 · Structural
Inflammation and aging: signaling pathways and intervention therapies
Li X et al. · 2023 · Signal Transduction Targeted Therapy, 2023
TIER 1
D-01 · Structural
IL-6, TNF, IL-1β and age-related diseases: meta-analysis
Tylutka A et al. · 2024 · Frontiers Immunology, 2024
TIER 3
D-01 · Structural
Serum ferritin as inflammatory disease marker
Kell DB et al. · 2014 · Metallomics, 2014
TIER 3
D-01 · Structural
Ferritin and cardiovascular/all-cause mortality
Kadoglou NPE et al. · 2017 · PLOS ONE, 2017
TIER 3
D-01 · Structural
Fasting glucose and cause-specific death
Seshasai SRK et al. · 2011 · NEJM, 2011
TIER 2
D-01 · Structural
Metabolic syndrome and all-cause mortality
Wu SH, Liu Z, Ho SC. · 2010 · Eur J Epidemiol, 2010
TIER 3
D-01 · Structural
Waist circumference as a vital sign: IAS/ICCR Consensus
Ross R et al. · 2020 · Nature Reviews Endocrinology, 2020
TIER 3
D-01 · Structural
Mitochondria in health, disease, and aging
Harrington JS et al. · 2023 · Physiological Reviews, 2023
TIER 3
D-01 · Structural
Mitochondrial and metabolic dysfunction in ageing
Miwa S et al. · 2022 · Nature Reviews Endocrinology, 2022
TIER 3
D-01 · Structural
Cardiorespiratory fitness as predictor of all-cause mortality and CV events
Kodama S et al. · 2009 · JAMA, 2009
TIER 2
D-01 · Structural
CRF is a strong predictor of morbidity and mortality: overview of meta-analyses
Lang JJ et al. · 2024 · Br J Sports Med, 2024
TIER 3
D-01 · Structural
VOâ‚‚max: a key predictor of longevity?
Strasser B, Burtscher M. · 2018 · Frontiers Bioscience, 2018
TIER 1
D-01 · Structural
HRV in prediction of mortality: meta-analysis
Jarczok MN et al. · 2022 · Neurosci Biobehav Rev, 2022
TIER 3
D-01 · Structural
HRV and Exceptional Longevity
Hernandez-Vicente A et al. · 2020 · Frontiers Physiology, 2020
TIER 3
D-01 · Structural
HRV and ANS imbalance: biomarkers of aging and inflammaging
Olivieri F et al. · 2024 · Ageing Research Reviews, 2024
TIER 3
D-01 · Structural
ANS imbalance during aging impairs anti-inflammaging strategies
Giunta S et al. · 2024 · GeroScience, 2024
TIER 1
D-01 · Structural
Resting heart rate and all-cause/CV mortality: meta-analysis
Zhang D et al. · 2016 · CMAJ, 2016
TIER 1
D-01 · Structural
Resting heart rate: dose-response meta-analysis
Aune D et al. · 2017 · Nutr Metab Cardiovasc Dis, 2017
TIER 1
D-01 · Structural
Blood pressure variability and cardiovascular disease: meta-analysis
Stevens SL et al. · 2016 · BMJ, 2016
TIER 3
D-01 · Structural
Composite physiological dysregulation as mortality predictor
Arbeev KG et al. · 2020 · Frontiers Public Health, 2020
TIER 3
D-01 · Structural
Short sleep and insomnia associated with accelerated epigenetic age
Kusters CDJ et al. · 2023 · Psychosomatic Medicine, 2023
TIER 3
D-01 · Structural
Sleep traits causally affect epigenetic age acceleration
Mendelian randomization study · 2024 · Scientific Reports, 2024
TIER 3
D-01 · Structural
Imbalanced sleep increases mortality risk by 14–34%
Ungvari Z et al. · 2025 · GeroScience, 2025
TIER 3
D-01 · Structural
Sleep regularity is a stronger mortality predictor than duration
Windred DP et al. · 2024 · Sleep, 2024
TIER 1
D-01 · Structural
Periodontal disease and CV/all-cause mortality: meta-analysis
Guo X et al. · 2023 · PLOS ONE, 2023
TIER 3
D-01 · Structural
Periodontal disease, systemic inflammation, and CV risk
Carrizales-Sepulveda EF et al. · 2018 · Heart Lung Circ, 2018
TIER 3
D-01 · Structural
ECM: structure, composition, biological functions, diseases, and therapeutic targets
Kamal KM et al. · 2026 · Molecular Biomedicine, 2026
TIER 3
D-01 · Structural
Remodeling and homeostasis of the ECM: implications for fibrosis and cancer
Cox TR, Erler JT. · 2011 · Disease Models Mechanisms, 2011
TIER 3
D-01 · Structural
HBOT increases telomere length and decreases immunosenescence
Hachmo Y et al. · 2020 · Aging, 2020
TIER 3
D-01 · Structural
Ozone therapy: pharmacodynamics, research, and clinical utility
Smith NL et al. · 2017 · Medical Gas Research, 2017
TIER 3
D-01 · Structural
Ozone treatment as integrative medicine: evidence-and-gap map
Serra MEG et al. · 2023 · Frontiers Public Health, 2023
TIER 3
D-01 · Structural
EBOO: controlled trial in peripheral artery disease
Di Paolo N, Bocci V et al. · 2005 · Int J Artif Organs, 2005
TIER 3
D-01 · Structural
Scientific and Medical Aspects of Ozone Therapy: State of the Art
Bocci VA. · 2006 · Arch Med Res, 2006
TIER 1
D-01 · Structural
Ozone major autohemotherapy in chronic fatigue (Univ. Bonn Dissertation)
Müller WJ. · 2007 · Univ. Bonn, 2007
What This Evidence Base Claims — And What it Does Not
A structured library is only credible when its limitations are surfaced as explicitly as its strengths. The framework names them on purpose.
No claim of clinical certainty
Evidence supports a structured risk read. It does not certify outcome and does not constitute diagnosis.
Evidence is dynamic
The library is reviewed on a defined cadence. Sources can be retired, demoted, or replaced as the literature evolves.
Tiering is transparent
Every reference is tier-classified by methodology. The framework does not promote weak studies into strong evidence.
Bias is acknowledged
Selection follows institutional protocol but is not blinded. Limitations are surfaced, not hidden.